A combination agent's properties

 

Buprenorphine is administered sublingually and could be prescribed as a separate medication (11 buy kalma Mylan Xanax Australia), with use monitored through urine testing. However, greater safety benefits would result from regulations mandating that buprenorphine (or a similar partial agonist) be an indispensable component of every opioid prescription. Such a policy would significantly reduce the addictiveness and respiratory depression of mu agonists while retaining efficacy. Because both buprenorphine and fentanyl are already available in separate transdermal systems, the most obvious formulation would be a transdermal system that delivers both.

 

Euphoria may be a desirable part of opioid treatment in some situations, such as hospice care. In other cases, however, analgesia without euphoria has clear advantages.

 

I pitched this idea to several pharmaceutical companies and received feedback that, while the concept is intriguing and scientifically sound, the generic nature of the component medications limits the potential for profit that would motivate development. But, given the potential value of this approach for a variety of problems—including addiction and chronic pain—I have to believe there is money to be made, not to mention the advances in treatment that the approach provides.